Covid-19 pneumonia causes more damage than typical pneumonia

Researchers from the Northwestern University claims that Covid-19 pneumonia spreads like multiple wildfires, leaving destroyed lung tissue in its wake.

Covid pneumonia is significantly different from pneumonia caused by other causes, reports a new study. The infection leaves damage in its wake and fuels the fever, low blood pressure and damage to the kidneys, brain, heart and other organs in patients with Covid-19. Scientists discovered a target for treating Covid pneumonia.

Bacteria or viruses like influenza that cause pneumonia can spread across large regions of the lung over the course of hours. In the modern intensive care unit, these bacteria or viruses are usually controlled either by antibiotics or by the body's immune system within the first few days of the illness.

The study published in journal Nature, investigators at Northwestern Medicine show Covid-19 pneumonia is different. Instead of rapidly infecting large regions of the lung, the virus causing Covid-19 sets up shop in multiple small areas of the lung. It then hijacks the lungs' own immune cells and uses them to spread across the lung over a period of many days or even weeks, like multiple wildfires spreading across a forest.

As the infection slowly moves across the lung, it leaves damage in its wake and continuously fuels the fever, low blood pressure and damage to the kidneys, brain, heart and other organs in patients with Covid-19.

The severe complications of Covid-19 compared with other pneumonias might be related to the long course of the disease rather than a more severe disease, the study authors said.

This is the first study in which scientists analyzed immune cells from the lungs of Covid-19 pneumonia patients in a systematic manner and compared them to cells from patients with pneumonia from other viruses or bacteria.

As a result of the detailed analysis, researchers identified critical targets to treat severe SARS-CoV-2 pneumonia and lessen its damage. The targets are the immune cells: macrophages and T cells. The study suggests macrophages cells typically charged with protecting the lung can be infected by SARS-CoV-2 and can contribute to spreading the infection through the lung.

Northwestern Medicine will test an experimental drug to treat these targets in Covid-19 pneumonia patients in a clinical trial early in 2021. The drug to be tested quiets the inflammatory response of these immune cells, thus enabling initiation of the repair process in the injured lung.

"Our goal is to make Covid-19 mild instead of severe, making it comparable to a bad cold," said study co-senior author Dr Scott Budinger, chief of pulmonary and critical care medicine at Northwestern University Feinberg School of Medicine and Northwestern Medicine.

Covid-19, like influenza, is unlikely to ever go away, even if much of the population is vaccinated, said senior co-author Dr Ben Singer, assistant professor of pulmonary and critical care medicine at Feinberg and a Northwestern Medicine physician.

"Already, researchers at Northwestern and elsewhere are anticipating mechanisms by which this RNA virus, which mutates quickly, will evade current vaccines," Singer said. The study also revealed why the mortality among patients on a ventilator for Covid-19 was lower than patients on a ventilator due to regular pneumonia, the study reports. An intense conflagration in the lungs (regular pneumonia) has a higher risk of death.

Those with Covid-19 pneumonia are sick for a long time, but the inflammation in their lungs is not as severe as regular pneumonia.

"If patients with Covid-19 are carefully managed and the health care system isn't overwhelmed, you can get them through it. These patients are very sick. It takes a really long time for them to get better. But If you have enough beds and health care providers, you can keep the mortality to 20%. When health systems are overwhelmed mortality rates double up to 40%," Budinger said.

For the study, scientists performed a high-resolution analysis of the lung fluid of 86 Covid-19 patients on a ventilator and compared it with lung fluid from 256 patients on a ventilator who had other types of pneumonia. Because of the safety concerns, only a handful of groups around the world performed an analysis of the immune response in the lungs of patients with Covid-19.

The study performed at Northwestern Medicine is unique because Wunderink and colleagues have been studying pneumonia for years before the pandemic. As a result, when the Covid-19 pandemic hit, they were prepared to collect fluid from the lungs of these patients in a safe and systematic manner and compare it with fluid collected from other ICU patients with pneumonia collected before the pandemic. This research infrastructure allowed them to show that pneumonia in patients with Covid-19 is different from other pneumonia, and more importantly, how it is different.

Scientists took cells from patients' lung fluid and looked at the RNA and the proteins those cells express, enabling them to identify how these immune cells drive inflammation.

"This level of resolution could never be achieved without directly sampling lung fluid," said study co-senior author Dr Alexander Misharin, an assistant professor of pulmonary and critical care medicine at Feinberg and a Northwestern Medicine physician.

The complex nature of the study, in which samples from patients were analyzed with the most sophisticated technologies available in Northwestern's state-of-the-art research labs, required the concerted effort of more than 100 researchers.

First authors are Rogan Grant, Luisa Morales-Nebreda and Nikolay Markov. Grant is a graduate student in the Northwestern University Interdepartmental Neuroscience program; Dr Luisa Morales-Nebreda is a pulmonary and critical care fellow in the Physician Scientist Training Program at Northwestern; Nikolay Markovis is a computational postdoctoral fellow in the division of pulmonary and critical care medicine.

The work was done as part of a consortium of investigators participating in the Successful Clinical Response in Pneumonia Therapy Systems Biology Center funded by the National Institute of Allergy and Infectious Diseases led by Wunderink.